These universal, silica-based, reversed-phase C18 columns are designed for polar compound retention. They feature di-functionally bonded C18 ligands optimized for use with highly aqueous mobile phases, including 100% water. These columns offer an ideal balance of retention for both polar and non-polar compounds, are fully LC/MS-compatible, and provide superior retention of polar compounds without excessive retention of hydrophobic compounds compared to conventional reversed-phase HPLC columns.
- Enhanced pH stability.
- Compatible with aqueous mobile phases.
- Superior peak shape.
- Low pH stability.
- Resists dewetting (hydrophobic collapse).
- Enhanced polar compound retention.
- Suitable for polar compound separation and standard reversed-phase applications.
- Extended column lifetime and stability under acidic mobile conditions (due to difunctional silane bonding).